MP-PALS is a true enabler for maximum sensitivity and short acquisition times. The combination of a powerful solid-state laser, precision optics and real parallel-plate electrodes near the optical path that do not distort electric field lines, permits application of low voltages with low current. Low voltage and current minimize perturbation of the sample, even in conductive solvents such as physiological saline, since exposure to high voltage may denature the sample and high currents produce heating and convection of the solvent, degrading the measurement.