Quartz Crystal Microbalance with Dissipation (QCM-D)

Quartz Crystal Microbalance with Dissipation (QCM-D) is a sensitive technique that measures minute changes in surface properties. It utilizes quartz crystals, where applied voltage causes oscillations. Deposited materials alter these oscillations, changing the resonant frequency and dissipation. Frequency shifts indicate mass changes, while dissipation reflects viscoelastic alterations. By tracking both, QCM-D provides data on layer mass, thickness, and rigidity. This enables studies of thin film formation, biomolecular interactions, and material characteristics. Crucial in biotechnology, pharmaceuticals, and materials science, QCM-D requires careful sensor selection for optimal results.

Advantages of QCM-D

• Allow continuous monitoring of adsorption processes as they occur.
• Preserves physiological relevance by avoiding the need for external tags or markers.
• Provides precise measurement of the bound mass on surfaces.
• Utilizes high frequency QCM sensors (HFF-QCM) for unparalleled detection capabilities.
• Study phase behavior of lipids, liquid crystals, and polymers.
• Works with various media including milk and seawater, expanding the application range.
• Includes liquid incorporated in the film.
• Assesses the mechanical properties of thin films.
• Measures and monitors the thickness of layers deposited on surfaces.
• Effective in both gas and liquid environments, making it adaptable to different experimental conditions.
• Can be combined with electrochemistry using a dedicated cell, enhancing experimental versatility.
• Suitable for extreme conditions, allowing measurements at elevated temperatures.

BioNavis MP-SPR delivers innovative solutions for cutting-edge molecular interaction and nanolayer characterization.